CD1B
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Official Full Name
CD1b molecule -
Overview
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. -
Synonyms
CD1B;CD1b molecule;CD1, CD1b antigen , CD1B antigen, b polypeptide;T-cell surface glycoprotein CD1b;CD1B antigen, b polypeptide;cortical thymocyte antigen CD1B;differentiation antigen CD1-alpha-3;R1;CD1;CD1A;MGC125990;MGC125991
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- Human Cells
- In Vitro Cell Free System
- His
- GST
- Non
- Fc
- DDK
- Myc
- Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CD1B-10918H | Recombinant Human CD1B, His-tagged | E.coli | Human | His | 124-206a.a. | |
| CD1B-0734H | Recombinant Human CD1B Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CD1B-2186C | Recombinant Chicken CD1B | Mammalian Cells | Chicken | His |
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| CD1B-27106TH | Recombinant Human CD1B | Wheat Germ | Human | Non | 92 amino acids |
|
| CD1B-27865TH | Recombinant Human CD1B | Wheat Germ | Human | Non | 333 amino acids |
|
| CD1B-344H | Recombinant Human CD1b molecule, His-tagged | E.coli | Human | His | 18-303 a.a. |
|
| CD1B-721R | Recombinant Rhesus monkey CD1B Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| CD1B-7331H | Recombinant Human CD1B protein(Met1-Ser303), hFc-tagged | HEK293 | Human | Fc | Met1-Ser303 |
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| CD1B-1504HCL | Recombinant Human CD1B cell lysate | Human Cells | Human | Non |
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| CD1B & B2M-1155R | Recombinant Rhesus CD1B & B2M protein(Met1-Ser303 & Met1-Met119), His-tagged | HEK293 | Rhesus macaque | His | Met1-Ser303 & Met1-Met119 |
|
| CD1b-0915H | Recombinant Human CD1b Protein (Ser18-Ser303), N-His tagged | E.coli | Human | His | Ser18-Ser303 |
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| CD1B-1211H | Recombinant Human CD1B Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| CD1B-151H | Recombinant Human CD1B Protein, His-tagged | Human Cells | Human | His |
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| CD1B-164H | Recombinant Human CD1B Protein, C-His-tagged | E.coli | Human | His |
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| CD1B-3009HF | Recombinant Full Length Human CD1B Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 333 amino acids |
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| CD1B-3039H | Recombinant Human CD1B Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| CD1B-317R | Recombinant Rhesus CD1B Protein, His-tagged | HEK293 | Rhesus macaque | His | Met1-Ser303 |
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| CD1B-5277H | Recombinant Human CD1B Protein (Met1-Ser303), C-Fc tagged | Mammalian Cells | Human | Fc | Met1-Ser303 |
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| CD1B-548R | Recombinant Rhesus Macaque CD1B Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| CD1B-548R-B | Recombinant Rhesus Macaque CD1B Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| CD1B-61HF | Recombinant Full Length Human CD1B Protein | In Vitro Cell Free System | Human | Full L. 333 amino acids |
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| RFL35963HF | Recombinant Full Length Human T-Cell Surface Glycoprotein Cd1B(Cd1B) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length of Mature Protein (18-333) |
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Involved Pathway
CD1B involved in several pathways and played different roles in them. We selected most pathways CD1B participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hematopoietic cell lineage | HLA-DRA,GP5,IL7R,ITGA1,IL2RA,IL4R,Flt3l,EPO,CD59,GYPA |
Protein Function
CD1B has several biochemical functions, for example, beta-2-microglobulin binding,endogenous lipid antigen binding,exogenous lipid antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD1B itself. We selected most functions CD1B had, and list some proteins which have the same functions with CD1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endogenous lipid antigen binding | CD1D2,CD1E,CD1C,CD1D,CD1A,CD1d1 |
| beta-2-microglobulin binding | HFE,HLA-A,CD1E,CD1D,CD1A,CD1C,H2-Q10,HLA-E,CD1D2,FCGRT |
| lipopeptide binding | CD1D2,CD1d1,CD1E,CD1D,TLR6,CD1A,CD1C |
| protein binding | UBA5,TBX1,FHOD1,CPSF3,UQCC1,FRMPD4,OIT3,TEF,SNX27,UBL5 |
| exogenous lipid antigen binding | CD1D,CD1E,CD1D2,CD1d1,CD1C,CD1A |
Interacting Protein
CD1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD1B here. Most of them are supplied by our site. Hope this information will be useful for your research of CD1B.
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References
- Romero-Palomo, F; Risalde, MA; et al. Immunohistochemical Detection of Dendritic Cell Markers in Cattle. VETERINARY PATHOLOGY 50:1099-1108(2013).
- Kalantari-Dehaghi, M; Anhalt, GJ; et al. Pemphigus Vulgaris Autoantibody Profiling by Proteomic Technique. PLOS ONE 8:-(2013).
